The project Modelling_Leukemia is devoted to the modelling of several aspects of Chronic Myeloid Leukemia. Leukemia
is the most famous disease of the blood cell formation process
(hematopoiesis). Chronic myeloid leukemia results in a uncontrolled
proliferation of abnormal blood cells. As the hematopoiesis involves
stem cells (not accessible to observations), mathematical modeling is
here a great tool to test hypothesis. We want to add up the expertise
of Inria team DRACULA
specialized on the modeling of blood cell formation and the Center for
Scientific Computation and Applied Mathematical Modeling (CSCAMM, University of Maryland, College Park).
Thomas Lepoutre , Inria Junior researcher , principal inevstigator on DRACULA side
Doron Levy, Full professor at CSCAMM and University of Maryland, Principal investigator on CSCAMM side
Dana Adriana Botesteanu, PhD student
Geoffrey Clapp, PhD student
Assia Wyatt, PhD student
Privileged medical contacts
Franck Nicolini (Lyon, France)
Peter Lee (City of Hope, US)
Recent and upcoming events concerning the team
short term visit of Doron Levy to Lyon
2 weeks visit of two PhD student of Doron Levy to Lyon (Dana Adriana Botesteanu and Geoffrey Clapp)
1 month visit of a PhD student to CSCAMM (Raouf El Cheik) February 2014.
short visit of Doron Levy to Lyon (beginning of December 2013) for discussion with Pr Nicolini.
beginning of the PhD thesis of Apoollos Besse on CML Modelling
short visit of Doron Levy and Geoffrey Clapp to Lyon (joint meeting with Pr Nicolini) end of October 2014
one week visit of Thomas Lepoutre to CSCAMM beginning of November 2014
three weeks visit of Apollos Besse to CSCAMM November 2014
one week visit of Thomas Lepoutre to CSCAMM June 2015
conference ESH John Goldman on CML ( October 2015, poster presentation)
one week visit of Apollos Besse and Thomas Lepoutre at CSCAMM (December 2015)
Reconduction of the team (2016)
Short visit of Doron Levy to Lyon (May 2016)
one week visit of Apollos Besse and Thomas Lepoutre at CSCAMM (October 2016)
Clapp, G. and Levy, D.
Incorporating Asymmetric Stem Cell Division into the Roeder Model for Chronic Myeloid Leukemia
Eladdadi, A., Kim, P. & Mallet, D. (ed.)
Mathematical Models of Tumor-Immune System Dynamics
Springer New York, 2014, pp. 1-20
Clapp, G. and Levy, D.
A review of mathematical models for leukemia and lymphoma
Drug Discovery Today: Disease Models, Elsevier BV, 2015, Vol. 16, pp. 1-6
Clapp, G. D., Lepoutre, T., El Cheikh, R., Bernard, S., Ruby, J., Labussière-Wallet, H., Nicolini, F. E. and Levy, D.
Implication of the Autologous Immune System in BCR-ABL Transcript Variations in Chronic Myelogenous Leukemia Patients Treated with Imatinib.
Cancer Res, 2015, Vol. 75(19), pp. 4053-4062
Clapp, G. D., Lepoutre, T., Nicolini, F. E. and Levy, D.
BCR-ABL transcript variations in chronic phase chronic myelogenous leukemia patients on imatinib first-line: Possible role of the autologous immune system
OncoImmunology, Informa UK Limited, 2016, Vol. 5(5), pp. e1122159
Besse, A., Lepoutre, T. and Bernard, S.
Long-term treatment effects in chronic myeloid leukemia.
Journal of Mathematical Biology, 2017
A. Besse, G. D. Clapp, S. Bernard, F. E. Nicolini, D. Levy, and T. Lepoutre Stability Analysis of a Model of interaction between the Immune System and Cancer Cells in CML Bulletin of Mathematical Biology 2017
Recent ommunications in conferences/ workshops.
ESH John Goldman conference Estoril, October 2015 (main medical conference on CML). Poster presentation (T. Lepoutre)
“Cancer: Math-Bio Workshop”, Howard University, December 2015. (D. Levy, invited)
Present challenges of mathematics in oncology and biology of cancer, December 2015 (A. Besse poster, T. Lepoutre oral communication)
StemCellMathLab’16: Systems Medicine of Leukaemia (S. Bernard oral communication)
“Applied Mathematics in Germinating Oncology Solutions”, National Cancer Institute, March 2016. (D. Levy, invited)
Department of Mathematics, Jiao Tong University, Shanghai, China, March 2016. (D. Levy, invited)
Department of Mathematics, Rutgers University, March 2016. (D. Levy, invited)
Department of Mathematics, Duke University, April 2016. (D. Levy, invited)
Workshop on "Models in Cancer Therapy" July 2016 (D. Levy, organizer)
ECMTB conference Nottingham July 2016 (A. Besse, oral communication)
“Integrative Cancer Research UMD-NCI Partnership”, Maryland, September 2017. (D. Levy inaugural invited talk)